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* immuno 7
 #134399  
  kashmala - 10/31/06 22:16
 
  A renal biopsy is performed on a 31-year-old female
who presents with increasing edema, chest pain, and a rash
for the past 6 months. She has an increasing serum creati-
nine level, and proteinuria with red blood cell casts is
found on urinalysis. The light microscopic appearance of
the renal biopsy is seen in the figure. It is stained with
periodic acid-Schiff stain. Which of the following antibod-
ies, if present, is diagnostic of this condition?
(D (A) Scl-70
(3 (B) Anti-Sin
(9 (C) Jo-1
O (D) Anti-HLA-B27
O (E) Anti-centromere
 
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* Re:immuno 7
#538445
  vl2ss - 10/31/06 22:18
 
  (E) Anti-centromere ??  
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* Re:immuno 7
#538473
  zarra - 10/31/06 22:32
 
  via elimination -- b

what is anti sin?
 
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* Re:immuno 7
#538477
  sage2006 - 10/31/06 22:33
 
  b..  
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* Re:immuno 7
#538495
  rmansour - 10/31/06 22:38
 
  What is Anti-Sin? DO YOU MEAN ANTI-SMITH. IF THIS IS THE CASE, IT'S LUPUS, AND THE ANSWER IS B

ANTI-SCL70 IS DIFFUSE SCLERODERMA, ANTI-JO IS FOR POLYMYOSITIS, ANTI-CENTROMERE IS FOR LOCALIZED SCLERODERMA (CREST SYNDROME)
 
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* Re:immuno 7
#538516
  sage2006 - 10/31/06 22:49
 
  it is anti-Sm.  
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* Re:immuno 7
#538526
  bep111 - 10/31/06 22:53
 
  eeeeeeee  
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* Re:immuno 7
#538538
  kashmala - 10/31/06 22:58
 
  correct answer is B
e is seen in limited scleroderma e.g CREST
 
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* Re:immuno 7
#538635
  zarra - 11/01/06 00:36
 
  kasmala - what is anti sin?  
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* Re:immuno 7
#538639
  kashmala - 11/01/06 00:38
 
  sory
was typing error i always make such mictakes
its Antismith antibodies...............for SLE
 
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* Re:immuno 7
#538649
  zarra - 11/01/06 00:58
 
  cool!! thanks kashmala -- I just wanted to make sure! Great questions!! Thanks for them!  
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