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* urinary frequency
 #134437  
  saonew - 11/01/06 01:35
 
  A 74-year-old man with urinary frequency and urgency
has benign prostatic hypertrophy. He refuses
operative intervention but agrees to a trial of
finasteride therapy. During the trial, synthesis of
which of the following substances is most likely to
be inhibited?
(A) Androstenedione
(B) Dihydrotestosterone
(C) Estradiol
(D) Estrone
(E) Testosterone
 
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* Re:urinary frequency
#538667
  zarra - 11/01/06 01:36
 
  b  
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* Re:urinary frequency
#538670
  edsoya - 11/01/06 01:42
 
  B  
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* Re:urinary frequency
#538672
  saonew - 11/01/06 01:43
 
  The correct answer is B. Finasteride is an inhibitor of 5-a-reductase, the
enzyme that converts testosterone (choice E) to dihydrotestosterone
(dihydrotestosterone causes prostate growth). Therefore, use of this agent
would inhibit dihydrotestosterone synthesis.
Androstenedione (choice A) is the precursor to testosterone. Androstenedione
synthesis would be unaffected by finasteride administration.
Testosterone is also a precursor to estradiol (choice C). Testosterone synthesis
would not be decreased by finasteride administration.
Estradiol is the precursor to estrone (choice D). Estradiol synthesis would not be
decreased by finasteride administration.
 
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* Re:urinary frequency
#805035
  tomkin - 06/11/07 15:37
 
  b is correct answer  
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* Re:urinary frequency
#2294018
  raheem - 12/19/10 22:54
 
  b- commonly exame asked Q,,,thanks  
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