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* repeated phlebotomy
 #324862  
  rehellohie - 08/02/08 14:40
 
  The use of repeated phlebotomy in the treatment of persons with symptomatic hemochromatosis may be expected to result in

A increased skin pigmentation
B improved cardiac function
C return of secondary sex characteristics
D decreased joint pain
E an unchanged 5-year survival rate
 
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* Re:repeated phlebotomy
#1406705
  vammfire - 08/02/08 14:44
 
  D decreased joint pain  
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* Re:repeated phlebotomy
#1406723
  rkelly2320 - 08/02/08 14:55
 
  BBB--just a guess  
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* Re:repeated phlebotomy
#1406725
  rkelly2320 - 08/02/08 14:56
 
  but confused between c and b it is either of one  
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* Re:repeated phlebotomy
#1406731
  rehellohie - 08/02/08 15:10
 
  The answer is B
In persons with symptomatic hemochromatosis, repeated phlebotomy, by removing excessive iron stores, results in marked clinical improvement. Specifically, the liver and spleen decrease in size, liver function improves, cardiac failure is reversed, and skin pigmentation ("bronzing") diminishes. Carbohydrate intolerance may abate in up to half of all affected persons. For unknown reasons, there is no improvement in the arthropathy or hypogonadism (resulting from pituitary deposition of iron) associated with hemochromatosis. The 5-year survival rate increases from 33 to 90 percent with treatment; prolonged survival may actually increase the risk of hepatocellular carcinoma, which affects one-third of persons treated for hemochromatosis. However, if phlebotomy is begun in the precirrhotic stage, which is possible with effective genetic screening, liver cancer will not develop.
 
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