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* Medicine question 28
 #531210  
  misshyd - 09/05/10 21:54
 
  A 55 y/o woman with history of well controlled DM Type II presents for her regular follow-up visit. She has no new complaints. She has been well controlled on Metformin alone with a hemoglobin A1c of 6.5. The patient is afebrile with a B.P 96/72, HR 88, RR 16. Physical examination is benign except for decreased sensation in her bilateral lower extremities consistent with diabetic neuropathy and bilater lower extremity edema. Her last urinary microalbumin about one year ago was negative. A repeat dipstick test now is positive for protein and blood but negative for leucoesterase and nitrite. Subsequent urine microscopy reveals 4 dysmorphic RBCs/HPF and red cell casts. Labs reveal elevated serum creatinine at 1.4 as opposed to her baseline creatinine of 0.8 6 months ago. The next important step in approaching this patient’s Renal Insufficiency is:

A) Obtain CPK level
B) 24 hour urine for microalbumin
C) Start ACE inhibitor
D) Repeat urinalysis in 3 months
E) Referral to Nephrologist and Renal biopsy
F) Start emperic antibiotic therapy for UTI

 
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* Re:Medicine question 28
#2187911
  jayshah - 09/05/10 22:01
 
  C....  
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* Re:Medicine question 28
#2187914
  misshyd - 09/05/10 22:02
 
  this is damnnn good question
tricking to the maximum
 
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* Re:Medicine question 28
#2187925
  diamox79 - 09/05/10 22:15
 
  Ideally I would have liked to do a spot urine microalbumin/creatinine ratio, at first. Anyways, I will choose B here.

Also, she is not hypertensive, so do not see any emergent need to start a ACE inhibitor. Had she been HTNsive, would consider that.
 
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* Re:Medicine question 28
#2187929
  jayshah - 09/05/10 22:21
 
  @diamox..it we suspect DM nephropathy.. then we start ACE INHI...irrespective of pt BP...  
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* Re:Medicine question 28
#2187934
  mos11 - 09/05/10 22:29
 
  CC  
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* Re:Medicine question 28
#2187935
  diamox79 - 09/05/10 22:29
 
  agree, I would start her on ACEI, but would like to see if I can consider B, and then start ACEI or would it be redundant?  
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* Re:Medicine question 28
#2187936
  diamox79 - 09/05/10 22:31
 
  agree, I would start her on ACEI, but would like to see if I can consider B, and then start ACEI or would it be redundant?  
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* Re:Medicine question 28
#2187938
  mos11 - 09/05/10 22:35
 
  diamox,pls correct me if i am wrong but i thought the test done to determine DM nephropathy is early morning ON the spot microalbuminaemia?  
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* Re:Medicine question 28
#2187941
  diamox79 - 09/05/10 22:44
 
  mos, the best test to screen for diabetic kidney disease is: spot urine microalbumin/creat ratio.
(not sure about microALBUMINEMIA ( did you mean albumniURIA?)

To confirm, just repeating the same spot urine microalbumin/creat ratio would be sufficient.

The above patient has microscopic hematuria, proteinuria, elveated creat making Intrinsic renal process, a possible cause for the hematuria. So infact, I am also tempted to consider, Biospy.

Lets wait for the explanation.
 
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* Re:Medicine question 28
#2187943
  mos11 - 09/05/10 22:46
 
  sorry for that diamox,its bed time for me,so making silly mistakes :)  
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