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* concepts of pathology only
 #564573  
  messi121212 - 01/26/11 11:59
 
  please explain your concepts and learn it twice. in real exams, you will only be judge by your concepts.








1. A 40-year-old man has the recent onset of right-sided chest pain, difficulty breathing, and fever. On auscultation he has crackles, decreased respiratory sounds, and evidence of a right-sided pleural effusion. Which of the following best describes the expected type of inflammatory process involving the lung?

A) Fibroblasts, collagen deposition, replacement of intrinsic tissue
B) Macrophages, lymphocytes, increased concentrations of immunoglobulins
C) Mast cells, histamine, smooth muscle contraction
D) Neutrophils, increased vascular permeability, edema
E) Vascular budding, fibroblasts, edema, proteoglycans



5. A 57-year-old man receives a sintered titanium oxide implant during total hip arthroplasty following traumatic injury. During the first 6 weeks following surgery, bone ingrowth anneals to the bone-metal interface in both the femur and acetabulum, thus securing the prosthesis in position. Type I collagen secretion in the first stage of matrix formation is mediated by which of the following cell types?

A) Chondroblasts
B) Chondrocytes
C) Endothelial cells
D) Macrophages
E) Osteoblasts
F) Osteoclasts
G) Osteocytes



23. explain a blood vessel, what is the principal site of nitric oxide action in producing vasodilation?




CELL INJURY
39. In reversible hypoxic cell injury, cellular swelling results from intracellular accumulation of
A) cholesterol
B) glycogen
C) phospholipid
D) potassium
E) sodium





CELL INJURY
22. An 18-year-old man attempts suicide by taking 15 g of acetaminophen. Four hours after the overdose, high levels of acetaminophen are found in the plasma. The most appropriate therapy is
A) hemodialysis
B) oral administration of aspirin
C) oral administration of N-acetylcysteine
D) respiratory support and watchful waiting
E) urinary alkalinization and forced diuresis



CELL INJURY
36. An adult's hemoglobin is 98% saturated with oxygen, but arterial oxygen content is decreased. The most likely cause of this condition is
A) anemia
B) an arteriovenous shunt
C) hemoglobinopathy
D) high-altitude hypoxia
E) pulmonary diffusion defect



MUSCULOSKELETAL
9. A 61-year-old woman has a 10-year history of progressive pain in the hips, knees, and hands. She has symmetric swelling and formation of nodules in the distal interphalangeal joints of her hands and pain on movement of both knees. There is no increased warmth or tenderness. The most likely cause of her joint pain is

A) gout
B) Lyme disease
C) osteoarthritis
D) pseudogout
E) rheumatoid arthritis


COAGULATION
10. A 3-year-old boy with cystic fibrosis is evaluated for the acute onset of an uncontrollable nosebleed. There is no family history of a bleeding disorder. A few large bruises are seen on the legs; no other abnormalities are noted. Prothrombin and partial thromboplastin times are prolonged. The patient's abnormalities are likely to improve with treatment using a cofactor for which process?

A) Carboxylation of prothrombin

B) Conversion of homocysteine to methionine

C) Farnesylation of ras

D) Hydroxylation of procollagen

E) Phosphorylation of pyruvate dehydrogenase



 
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* Re:concepts of pathology only
#2317417
  messi121212 - 01/26/11 12:01
 
  i will return tonight after i review fa. good luck.

no fighting please.
 
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* Re:concepts of pathology only
#2317548
  bedidee - 01/26/11 15:11
 
  1-C
39-E
22-C
36-A
 
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* Re:concepts of pathology only
#2317558
  parvus - 01/26/11 15:37
 
  1) D
2) B
39) E
22) C
36) A
9) E
10) A??
23) ???????
 
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* Re:concepts of pathology only
#2317589
  docnas - 01/26/11 16:13
 
  1- D- he has an infection first defence called in is the neutrophils

5-C- correct me if im wrong but endothelial cells secrete FGF which is the first step?

23- i have no idea what u mean?

39-e- hypoxia ->shutting off of Na/K channels =Inc in NA = cellular swelling

22-C- Nacetylcystine is a precursor of glutathione which increases the conjugation of teh toxic metabiolite of acetomenophin.

36-A- I remember this from somewhere else it basically said blood loss = anemia = less oxgen carried in the blood ( i think just diffused into it not carried by hemoglobin) =decrease o2 content

9-c- those nodules arent they herberden nodules which are pathmogmonic for osteoarthritis

10-?- i know he has CF-which leads to malabsorbtion and other vitamin deficiencys so maybe ur refering to vit K deficiency but i have no idea where that effects though.
 
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* Re:concepts of pathology only
#2317600
  srk123 - 01/26/11 16:35
 
  i agree with docnas for all the answers 23 ans is smuth muscle nbme 2 q  
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* Re:concepts of pathology only
#2317607
  bedidee - 01/26/11 16:50
 
  sorry 1-D not C  
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* Re:concepts of pathology only
#2317637
  doc_study - 01/26/11 17:11
 
  1. D. Pneumonia= Acute inflamation

5. A. not sure just a guess .....

23. Couldn't understand the Q. but the mech. of NO is activation of Guanyl cyclase & inc cGMP which mediates vasodilation.

39. E. Low ATP. Inactivation of Na/K pump. Inc in intracellular Na = cellular swelling

22. C. Antidote for acetaminophen poisoning.

36. A. Dec. oxygen content & normal O2 sat. is anemia

9. C. Osteoarthritis. Old age & Heberden's Nodes.

10. Vit . K def. due to malabsorption of fat soluble vitamins due to CF.
 
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* Re:concepts of pathology only
#2317699
  step1success - 01/26/11 18:58
 
  1. D
5. C
39. E
22. C
36. A
9. C
10. A??
 
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* Re:concepts of pathology only
#2317847
  drmam - 01/26/11 22:46
 
  1. D
5. A
23. S muscle
39. E
9. C
10.a
 
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* Re:concepts of pathology only
#2318123
  elpida - 01/27/11 13:41
 
  Hello,

Could you please post answers?

Thank you so much,

Elpida
 
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