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* expalin milk alkali syndrome
 #570970  
  angelman1 - 02/28/11 13:48
 
  what is milk alkali syndrome and how does it cause increased calcium..someone explain  
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* Re:expalin milk alkali syndrome
#2341470
  angelman1 - 02/28/11 13:52
 
  someone?  
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* Re:expalin milk alkali syndrome
#2341473
  puo - 02/28/11 13:55
 
  something to do with calcium carbonate interaction ........? dont know properly ...sry  
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* Re:expalin milk alkali syndrome
#2341488
  angelman1 - 02/28/11 14:11
 
  thanks for ur response:)  
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* Re:expalin milk alkali syndrome
#2341490
  puo - 02/28/11 14:11
 
  is characterized by hypercalcemia caused by repeated ingestion of calcium and absorbable alkali (such as calcium carbonate, or milk and sodium bicarbonate). If untreated, milk-alkali syndrome may lead to metastatic calcification and renal failure.

The name "milk-alkali syndrome" derives from when patients would take in excessive amounts of milk and antacids to control their dyspepsia, as prescribed by the "Sippy regimen", leading to overingestion of two key ingredients that lead to the disorder, excess calcium and excess base. Ingesting over two grams of elemental calcium per day produces this disorder in susceptible individuals. Gastrointestinal absorption of such a large amount of calcium leads to hypercalcemia. This inhibits parathyroid hormone secretion by the parathyroid gland and may also lead to diabetes insipidus. The body's attempt to rid itself of the excess base in the urine may cause bicarbonaturia and subsequent hypovolemia due to transport of sodium ions to accompany the bicarbonate.

wikipedia
 
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* Re:expalin milk alkali syndrome
#2341494
  maryam2009 - 02/28/11 14:12
 
  Milk-alkali syndrome is caused by the ingestion of large amounts of calcium and absorbable alkali with resulting hypercalcemia. If unrecognized and untreated, milk-alkali syndrome can lead to metastatic calcification and renal failure.

Calcium absorption is completed within 4 hours of intake. Avid absorption of large doses may lead to suppression of parathyroid hormone (PTH), which then produces enhanced bicarbonate retention by the kidney. Continuing ingestion of calcium carbonate and bicarbonate retention leads to alkalosis, which causes increased calcium resorption in the distal collecting system of the kidney. Also, hypercalcemia produces a renal concentrating defect that can be considered a form of nephrogenic diabetes insipidus.

 
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* Re:expalin milk alkali syndrome
#2341496
  angelman1 - 02/28/11 14:14
 
  thanks to both of u  
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