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* NBME form 12 block 2 q 43
 #610012  
  hnin - 08/28/11 15:30
 
  In a study of mutation that reduce the activity cytoplasmic enzymes, A mutation is found that results in substituting of an alanine residue for the serine residue normally present at position 127 in the enzyme, This mutation is most likely to reduce the activity of the enzyme by preventing which of the following?
A) Attachment of famesyl groups
B) Attachment of N linked oligosaccharides
C) Formation of disulfide bonds
D) Phosphorylation of the enzyme
E) Targeting the enzyme to the correct cellular location
MY answer is B
Please correct me if I wrong
 
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* Re:NBME form 12 block 2 q 43
#2459163
  bedidee - 08/28/11 16:55
 
  i think it should be d... as serine and threnione participate in phophorylation...  
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* Re:NBME form 12 block 2 q 43
#2459180
  hnin - 08/28/11 17:55
 
  Thank you, bedidee.  
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* Re:NBME form 12 block 2 q 43
#2459189
  bedidee - 08/28/11 18:05
 
  u r welcome...  
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* Re:NBME form 12 block 2 q 43
#2459215
  happydoctor - 08/28/11 19:26
 
  ddd. b/c serine is usually the phosphorylation site for lots of signaling pathway. like MAPK. INSULINE()  
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* Re:NBME form 12 block 2 q 43
#2611345
  step1fire - 03/11/12 20:58
 
  plz explain ....  
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* Re:NBME form 12 block 2 q 43
#2611377
  my250 - 03/11/12 21:31
 
  In prokaryotic proteins phosphorylation occurs on the serine, threonine, tyrosine, histidine or arginine or lysine residues.  
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* Re:NBME form 12 block 2 q 43
#2841904
  doctoroesperanto - 03/01/13 13:03
 
  S T T H A L thankyu  
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