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* nbme 7:ques 30 block 4 PLEASE HELP!!! :( :(
 #662782  
  likewtf - 03/15/12 09:38
 
  A 23-year-old woman comes to the physician because of a 6-month history of lethargy and fatigue; she has had a 9-kg (20-lb) weight loss during this period. Physical examination shows a generalized increase in pigmentation of the skin and buccal mucosa. Her blood pressure is 104/70 mm Hg while supine and 86/60 mm Hg while standing. Serum studies show:

Na+ 129 mEq/L
K+ 5.7 mEq/L
Glucose 64 mg/dL
Aldosterone 0.5 ng/dL (N=310)

Which of the following changes in renal function is a direct result of the abnormal serum aldosterone concentration in this patient?

A) Decreased glomerular filtration rate

B) Increased renin secretion

C) Increased sodium in the urine

D) Increased water resorption from the distal tubules

E) Proteinuria



OKay so i was between a b and c, since hypotension -> decreased GFR, increase renin secretion, also sodium loss bc of lack of aldosterone - addisons disease

can someone explain me what the ans is please...
 
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* Re:nbme 7:ques 30 block 4 PLEASE HELP!!! :( :(
#2617014
  dreddy - 03/15/12 10:33
 
  C...they are talking about addisons disease---> you have dec aldosterone...and the main thing they are asking is "changed in renal function is a direct result of the abnormal serum aldosterone conct" thats the key in the questions...

yeah you can get inc renin but pertaining to the addisons which is the best answer....

it would be increased sodium in the urine...

hope that helps
 
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* Re:nbme 7:ques 30 block 4 PLEASE HELP!!! :( :(
#2617024
  maryam2009 - 03/15/12 10:39
 
  C..

We are asked about... the.direct result of the abnormal serum aldosterone concentration


Aldosterone promotes the activity of Na/K-ATP ase -dependent pump that moves Na+ into the renal ECF in exchange for K+.,Aldosterone also increses the Number of Na+ channels in the LUMINAL MEMBRANE....the tubule lumen becomes more negatively charged than the ECF......attracts K+ and H+...faciliates their secration into the distal tubule/collecting duct...
..
 
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* Re:nbme 7:ques 30 block 4 PLEASE HELP!!! :( :(
#2617036
  likewtf - 03/15/12 10:55
 
  thanks soo much! makes sense now :) u guys are the best :)  
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