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* HELP to answer: Thyroglobulin level
 #741762  
  exam.step1 - 07/22/13 16:36
 
  1-In Hashytoxicosis ( T4 at the beginning of the disease is elevated)

2- In subacute thyroiditis

3- In Garve's

4- In Papillary carcinoma

5- Thyrotoxicosis fatcticia

6- Struma Ovarii

Thanks in advance !



 
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* Re:HELP to answer: Thyroglobulin level
#2917256
  happyusmle1 - 07/22/13 19:03
 
  I think all high except exogenous thyroid on the list. Good differentiating lab test.
Tnx.
 
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* Re:HELP to answer: Thyroglobulin level
#2917294
  greya - 07/22/13 20:31
 
  all high..

what is fatcticia???
 
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* Re:HELP to answer: Thyroglobulin level
#2917326
  exam.step1 - 07/22/13 21:43
 
  @ Greya: someone taking or abusing levothyroxin

@ happyusmle

In facticia TG is normal but I am not sure in graves , cancer and in hashimato thyroiditis

in all them there there is ab against TG , so I couldnt find what will be the level of TG

I also not sure in struma ovarii!

appreciate it if someone can help!
 
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* Re:HELP to answer: Thyroglobulin level
#2917329
  happyusmle1 - 07/22/13 21:53
 
  I know for exogenous, tg is low not normal. And my understanding is tg is high in all other you stated including struma ovarii. I will check a reference and get back to be 100% sure.
 
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* Re:HELP to answer: Thyroglobulin level
#2917332
  exam.step1 - 07/22/13 22:05
 
  Thanks!  
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* Re:HELP to answer: Thyroglobulin level
#2917334
  psychmledr - 07/22/13 22:11
 
  Here is some information:

http://emedicine.medscape.com/article/2089532-overview#showall

Thanks for bringing it up :)
 
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* Re:HELP to answer: Thyroglobulin level
#2917368
  happyusmle1 - 07/23/13 00:35
 
 


Ok exam .step1:

This is based on two references:


Normal < 33 ng/mL

*Useful for following recurrences of nonmedullary thyroid carcinoma*

INCREASED:
Differentiated thyroid carcinoma (papillary, follicular), Graves disease, nontoxic euthyroid or hyperthyroid goiter,
Subacute thyroiditis

DECREASED:
Hypothyroidism, testosterone, steroids, phenytoin, exogenous levothyroxin

:)
 
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* Re:HELP to answer: Thyroglobulin level
#2917404
  exam.step1 - 07/23/13 01:41
 
  THANK YOU :)  
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* Re:HELP to answer: Thyroglobulin level
#2917407
  exam.step1 - 07/23/13 01:45
 
  @ psychmledr :

indeed thanks to you as your question few days back made me to think about it!
But here TG was normal in the Q!!!

A 31-year-old female complains of a 2-month history of a 15-lb unintentional weight loss, anxiety, and "feeling jittery." The neck examination is unremarkable. Physical examination shows tachycardia and increased deep tendon reflexes. Thyroid-stimulating hormone (TSH) is below 0.01. Total T4 is elevated. Whole-body radionuclide iodine scan shows only low uptake in the region of the thyroid. Serum thyroglobulin levels are within the normal range. What is the most likely diagnosis?

A. Graves' disease
B. Struma ovarii
C. Subacute thyroiditis
D. Lymphocytic thyroiditis
E. Thyrotoxicosis factitia
F. Pregnanc
 
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* Re:HELP to answer: Thyroglobulin level
#2917408
  exam.step1 - 07/23/13 01:46
 
  THANKS happyusmle for your nice help!  
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