 
* Crazy 2 
 #846105 




A healthy 22yearold man who weighs 70 kg (154.3 lb) volunteers for a phase I clinical trial investigating the properties of a newly developed antimicrobial agenl The drug ls found to have a volume of distribution of 10 L and exhibits firstorder elimination kinetics. The rate of drug clearance is calculated to be 7 L/hr. It is determined that repeating the second dose when 75% of the drug is eliminated will minimize toxicity while maintaining trough levels above the minimum inhibitory concentration. Based on these research findings, which of the following is the most appropriate dosing interval for this drug?
A. 1 hour
B. 1.5 hours
C. 2 hours
D. 2.5 hours
E. 3 hours


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* Re:Crazy 2 
#3354499 


Yup its C. Took me awhile to get. 75 cleared would be two half lives. Half life is 1 hr from this drug. Great questions. Thank you! 

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* Re:Crazy 2 
#3354508 


t1/2 = Vd x 0.7/ Cl
plug into this formula i.e 10x 0.7/7= 7/7= 1.
now to eliminate 75% of drug , 2 half life are needed therefore, 2hr.
so C is the correct answer.


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