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* Step 1 stuff
 #846209  
  2pac - 12/10/17 18:20
 
  Apoptosis, or programmed cell death, is understood to be a distinctive cellular function. Which of the following proteins acts to inhibit apoptosis?

A. Bcl-2
B. Bax
C. Bad
D. Cytochrome C


2. Nitroglycerin cgmp
3. Pheo : neural crest
4. Winged scapula long thoracic nerve
5. Levothyroxine overdose q
6. Leuprolide gnrh analogous continues brings down fsh lh , flutamide for prostate cancer
 
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* Re:Step 1 stuff
#3354798
  2pac - 12/10/17 18:22
 
  Went over nbme 12 from step 1, gosh brough back memories

People told me step 1 stuff showed up so I’m reviewing as much as I can here and there

Thymidine dimers in which child genetic disease
 
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* Re:Step 1 stuff
#3354799
  2pac - 12/10/17 18:23
 
  ARR

NNT = 1/ ARR

Convert percentage to decimal!!!

 
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* Re:Step 1 stuff
#3354800
  2pac - 12/10/17 18:34
 
  Erlichia treatment! White low wbc
Babesia treatment! Rbc low hemolytic anemiA
Lyme

All are from ixodes tick
 
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* Re:Step 1 stuff
#3354850
  2pac - 12/11/17 11:51
 
  verapramil quinidine and amiodarone by decreasing Clearance---> Digoxin toxicity
Furosemide by decreasing K. low K ----> Digoxin toxicity

FA step 1
 
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* Re:Step 1 stuff
#3354851
  2pac - 12/11/17 12:29
 
  Anthracyclines (Daunorubicin, doxurubicin, epirubicin, and idarubicin)
duxorubicin:::: FREE RADICALS generate and it causes DCM
how to reverse it? DEXRAZONE : Irone chelating agent that decreases formation of oxygen free radicals by doxorubicin


unbelieavble i didn't know this. read this !
 
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* Re:Step 1 stuff
#3354865
  2pac - 12/11/17 15:41
 
  HMG-CoA reductase
inhibitors
(eg, lovastatin,
pravastatin)
􀁲􀁲􀁲 􀁱 􀁲 Inhibit conversion of HMGCoA
to mevalonate, a
cholesterol precursor;
􀁲 mortality in CAD patients
Hepatotoxicity (􀁱 LFTs),
myopathy (esp. when used
with fibrates or niacin)
Bile acid resins
Cholestyramine,
colestipol,
colesevelam
􀁲􀁲 Slightly 􀁱 Slightly 􀁱 Prevent intestinal reabsorption
of bile acids; liver must use
cholesterol to make more
GI upset, 􀁲 absorption of
other drugs and fat-soluble
vitamins
Ezetimibe 􀁲􀁲 􀁱/— 􀁲/— Prevent cholesterol absorption
at small intestine brush
border
Rare 􀁱 LFTs, diarrhea
Fibrates
Gemfibrozil,
bezafibrate,
fenofibrate
􀁲 􀁱 􀁲􀁲􀁲 Upregulate LPL 􀁰 􀁱 TG
clearance
Activates PPAR-α to induce
HDL synthesis
Myopathy (􀁱 risk with
statins), cholesterol
gallstones
Niacin (vitamin B3) 􀁲􀁲 􀁱􀁱 􀁲 Inhibits lipolysis (hormonesensitive
lipase) in adipose
tissue; reduces hepatic VLDL
synthesis
Red, flushed face, which is
􀁲 by NSAIDs or long-term
use
Hyperglycemia
Hyperuricemia
PCSK9 inhibitors
Alirocumab,
evolocumab
􀁲􀁲􀁲 􀁱 􀁲 Inactivation of LDL-receptor
degradation, increasing
amount of LDL removed
from bloodstream
Myalgias, delirium,
dementia, other
neu
 
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* Re:Step 1 stuff
#3354866
  2pac - 12/11/17 15:42
 
  cum
PCSK9 inhibitors
Alirocumab,
evolocumab
􀁲􀁲􀁲 􀁱 􀁲 Inactivation of LDL-receptor
degradation, increasing
amount of LDL removed
from bloodstream
Myalgias, delirium,
dementia, other
neuPCSK9 inhibitors
Alirocumab,
evolocumab
􀁲􀁲􀁲 􀁱 􀁲 Inactivation of LDL-receptor
degradation, increasing
amount of LDL removed
from bloodstream
Myalgias, delirium,
dementia, other
neu
 
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* Re:Step 1 stuff
#3354867
  2pac - 12/11/17 15:53
 
  patient on statin and has red urine whichdrug cause this? a cyt 450 inhibitor!!!!!

Inhibitors (–)

Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Acute alcohol abuse
Chloramphenicol
Erythromycin (macrolides)
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
SICKFACES.COM
 
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* Re:Step 1 stuff
#3354887
  2pac - 12/11/17 20:19
 
  Allopurinol Competitive inhibitor of xanthine oxidase.
􀁲 conversion of hypoxanthine and xanthine to
urate. Also used in lymphoma and leukemia
to prevent tumor lysis–associated urate
nephropathy. 􀁱 concentrations of azathioprine
and 6-MP (both normall
 
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* Re:Step 1 stuff
#3354888
  2pac - 12/11/17 20:21
 
  good explanation in step 1 kaplan book.. for allopurinol  
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