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* lactic acidosis
 #852086  
  zalak148 - 06/12/18 08:56
 
  hey! can someone please explain how impaired gluconeogenesis or glycogenolysis causes lactic acidosis?  
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* Re:lactic acidosis
#3368043
  cardio69 - 06/12/18 14:38
 
  Lactic acid produced by anaerobic or aerobic glycolysis world?
Can be oxidized to CO2 & & what in TCA cycle? Or how you think can reconvert -> to sugar in hep?
 
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* Re:lactic acidosis
#3368066
  zalak148 - 06/12/18 15:45
 
  oh ok so the only way to get rid of lactic acid is through gluconeogenesis!! did I get it right? thanks in advance :)  
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* Re:lactic acidosis
#3368068
  cardio69 - 06/12/18 16:17
 
  You didn’t answer my Q:) that's not what u ask here.

Let’s try again; to take you home.
How you think from pahtophyso your pov, we classify the lactic acidosis?
 
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* Re:lactic acidosis
#3368071
  zalak148 - 06/12/18 16:43
 
  alright! I will try. lactic acid is produced by anaerobic glycolysis. it cannot be oxidized to CO2 or enter TCA cycle. and at last lactic acidosis classification- I don't know the exact classification but it may be caused by increased metabolism, decreased O2 supply or decreased blood flow to liver.  
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* Re:lactic acidosis
#3368080
  cardio69 - 06/12/18 17:55
 
  “Lactic acid” created by anaerobic glycolysis & we could say may either be oxidized -> CO2 & WATER or in liver/hep reconvert -> Sugar. You understand TCA cycle & gluconeogenesis NEED O2. Now, in anaerobic glycolysis is NON O2 requiring path.

We can classified lactic acidosis; HYPOXIC OR NON HYPOXIC or type A & type B.

i.e.; ischemia or septic fall in hypoxic and B1 def or let say methanol/or CN- fall in NON hypoxic (long list)
 
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* Re:lactic acidosis
#3368093
  zalak148 - 06/13/18 05:36
 
  okay but still how do you explain lactic acidosis in impaired gluconeogenesis? if lactic acid can be metabolised to CO2 and water
 
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* Re:lactic acidosis
#3368123
  cardio69 - 06/13/18 16:30
 
  All my Qs should have open that ans for you.
In general term ( bz I don’t know what’s your specific Q on “gluconeogenesis”)

Lactic acidosis can result of inhibition of LACTATE* utilization in gluconeogenesis (e.g. as you know let say defect in aldolase in HFI pat Or anther exp for you; in G 6-P def as you see all path that use glucose 6-P block, G/6-P can be shunted -> glycolysis & -> lactate produce.

So, if in any cases combo or solo effect of impaired gluconeogenesis (& ↑ anaerobic glycolysis pic converts in the liver) from an organ that consumes* & H to 1 that generate huge amounts -> lactic ACID. Let say in cases of hypoxia in your pat with cardiac arrest -> you see marked lactic acidosis…

And for you last confusion; "if lactic acid can be metabolised to CO2 and water" WHAT DID I SAY YOU NEED IN TCA CYCLE & gluconeogenesis to oxidize them/lactic acid -> CO2 and water ?
 
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