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* Fred biostatistic question / explanation needed
 #851099  
  ahmedcsck - 05/11/18 01:01
 
  A phase 2, multicenter trial was conducted to determine the efficacy of a new vaccine for prevention of HIV infection. The study enrolled 4000 subjects, aged 20 to 65 years. Of these subjects, 2100 were men and 1900 were women; 2500 were white, 1000 were African American, 300 were Hispanic, and 200 were Asian/Pacific Islanders. Results of the trial showed no overall benefit of the vaccine. However, post hoc analysis disclosed a small but statistically significant vaccine protection among African American subjects. Which of the following is the most accurate rationale for questioning the validity of efficacy analysis of the HIV vaccine among the African American study subjects?

(A) Allocation bias favored African American subjects
(B) HIV infection is more prevalent among African American populations
(C) The study was not blinded
(D) There was a Type II error
(E) Vaccine response among African American subjects was not the primary outcome measure


The answer should be E
 
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* Re:Fred biostatistic question / explanation needed
#3366744
  rpl - 05/14/18 14:15
 
  Ans should be D. there is a type 11 error due to confounding bias.
 
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* Re:Fred biostatistic question / explanation needed
#3366948
  ahmedcsck - 05/18/18 22:45
 
  No Buddy, this is one of the Fred questions for step3 and their answer is E.  
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* Re:Fred biostatistic question / explanation needed
#3366965
  lamonti - 05/19/18 10:05
 
  True. types of outcome measure could be primary, secondary, or post hoc. The results among AA was a post hoc, not a primary outcome measure.  
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