08-17-2014, 03:06 PM
A 61-year-old man with acute myelogenous leukemia admitted for induction chemotherapy is started on empiric vancomycin and cefepime for an episode of febrile neutropenia on hospital day 9. On hospital day 15 he develops a morbilliform rash over his lower posterior trunk. He is otherwise feeling well and has no other skin or mucous membrane lesions, but he remains neutropenic.
What is the best next step in management?
A.Change cefepime to aztreonam
B.Change cefepime to levofloxacin
C.Change vancomycin to daptomycin
D.Change vancomycin to linezolid
E.Continue current therapy