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Clearance=100mL/min
Vd=50 L
T1/2=3 hours

Assuming that the drug is being administered intravenously, what loading dose should be given to a patient to quickly obtain a plasma concentration of 10 mg/L?

A 5 mg
B 25 mg
C 100 mg
D 500 mg
E 1,000 mg

D)
Loading dose = Cp × Vd/F.
where Cp = target plasma concentrations
and F = bioavailability.

LD=10mg/Lx50L=500MG

Assuming the bioavailability is 100%, the ans. is D.