Which agent functions by binding to ergosterol and leads to pore formation and cell destruction?
A) Bacitracin
B) Terbinafine
C) Metronidazole
D) Ketoconazole
E) Amphotericin B
E correct
Amphotericin B is an antifungal agent that is used for severe systemic fungal infections, and also has a terrible side effect profile (aka "amphoTERRIBLE") with chills, hypotension and nephrotoxicity being a few.
Bacitracin is a topical bacterial cell wall synthesis inhibitor that prevents transfer of mucopeptides into the growing cell wall.
Terbinafine is an allylamine derivative that inhibits squalene epoxidase, resulting in ergosterol deficiency within the fungal cell wall and death.
Ketoconazole blocks fungal cytochrome P450, which inhibits biosynthesis of triglycerides and phospholipids by fungi.
Metronidazole damages DNA.