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An elderly individual is admitted to a hospital after a long period in which the family had complained that he had showed increasing incidences of disorientation coupled with memory loss. The patient was diagnosed with Alzheimer™s disease and a few years later, after further physical and mental deterioration, the patient died. An autopsy was taken of his brain and regional brain chemistry and neuropathology identified. One neurotransmitter most often implicated in this disorder with respect to the affected brain regions is ?
1. Histamine

2. Substance P

3. ACh

4. Enkephalin

5. Dopamine
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