A 30-year-old female with partial seizures is treated with vigabatrin. What is the principal mechanism of action of vigabatrin?
A.
Sodium channel blockade
B.
Increase in frequency of chloride channel opening
C.
Increase in GABA
D.
Calcium channel blockade
E.
Increased potassium channel permeability
F.
NMDA receptor blockade
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The answer is: C
Vigabatrin is useful in partial seizures. It is an irreversible inhibitor of GABA aminotransferase, an enzyme responsible for the termination of GABA action. This results in accumulation of GABA at synaptic sites, thereby enhancing its effect
best way to remember this one is Vi"GABA"trin. thanks.
Yes. Would like to add this here.....
Vigabatrin blocks GABA transaminase......this is also one of the multiple Mechanisms by which Valproic acid acts (V for both Viagabin and Valproic acid) Also Vigabatrin causes Visual dysfunction. again V
Tiagabin blocks GABA TRANSPORTER
Both Vigbatrin and Tiagabin would increase GABA , and both useful in partial seizures.