nbme q 135
#137662
myusmle - 11/10/06 22:32
A 20-year-old man has had increasingly severe muscle weakness and incapacitation. He has used a wheelchair for ambulation since he was 10 years of age. Examination of tissue obtained on biopsy of a calf muscle when he was 6 years old showed a mixed pattern of muscle fiber necrosis alternating with hypertrophy and regeneration of residual muscle fibers. At age 18 years, biopsy findings showed virtually complete replacement of muscle by fibrofatty tissue. Which of the following cellular proteins is most likely to be missing from this patient's muscles?
A ) Actin
B ) Desmin
C ) Dystrophin
D ) Spectrin
E ) Vimentin
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* Re:nbme q 135
#554231
rmansour - 11/10/06 22:38
CCC: DMD
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* Re:nbme q 135
#554278
myusmle - 11/10/06 23:00
c --
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* Re:nbme q 135
#554286
pranju - 11/10/06 23:06
CCCCCCccc
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* Re:nbme q 135
#554303
prams - 11/10/06 23:14
cccc
nbme 141
#137668
myusmle - 11/10/06 22:34
A 42-year-old woman reports fatigability, nervousness, irritability, and heat intolerance. She has a diffuse goiter, exophthalmos, and pretibial edema. Circulating antibodies to which of the following are most likely to be found in this patient?
A) Microsomal protein
B) Reverse triiodothyronine (rT3)
C) Thyroglobulin
D) Thyrotropin
E) Thyrotropin receptor
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* Re:nbme 141
#554222
rmansour - 11/10/06 22:36
EEE: SHE HAS GRAVES DISEASE.
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* Re:nbme 141
#554296
myusmle - 11/10/06 23:10
ok i agree
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* Re:nbme 141
#554300
pranju - 11/10/06 23:11
yup
nbme 142
#137669
myusmle - 11/10/06 22:34
A 68-year-old man has heterozygous familial hypercholesterolemia. Which of the following agents will decrease plasma VLDL and LDL concentrations but will cause cutaneous vasodilation that subsides with repeated doses?
A) Niacin
B) Nitric oxide
C) Prostacyclin (PGI2)
D) Prostaglandin E2
E) Substance P
F) Thyroxine (T4)
G) Vasoactive intestinal polypeptide
H) Vitamin B6 (pyridoxine
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* Re:nbme 142
#554218
rmansour - 11/10/06 22:35
AAA: NIACIN CAUSES FLUSHING AS A SIDE EFFECT.
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* Re:nbme 142
#554294
myusmle - 11/10/06 23:09
ok aaaaa
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* Re:nbme 142
#554298
pranju - 11/10/06 23:10
AAAAAAA asprin does help too
nbme 139
#137666
myusmle - 11/10/06 22:33
A 63-year-old woman has pain in the back. An x-ray film of the spine shows a vertebral compression fracture. Measurement of bone mineral density is markedly below the reference range. Serum concentrations of calcium, phosphorus, albumin, and creatinine, and activity of alkaline phosphatase are all within the reference range. Urine calcium and protein concentrations are normal. The most likely diagnosis is
A) Fanconi's syndrome
B) hyperparathyroidism
C) osteitis deformans (Paget's disease)
D) osteomalacia
E) osteoporosis
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* Re:nbme 139
#554226
rmansour - 11/10/06 22:37
EEE: IN OSTEOPOROSIS THE LAB VALUES ARE NORMAL!!
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* Re:nbme 139
#554233
michaelis - 11/10/06 22:39
ee
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* Re:nbme 139
#1424957
farabi - 08/19/08 04:24
Osteoporosis
nbme q 136
#137663
myusmle - 11/10/06 22:32
A 32-year-old woman who is an editor for a publishing company comes to the physician because of intermittent diarrhea for the past 10 years, which occurs three to four times per year, lasts 2 to 4 days, and is associated with deadlines at work. During these episodes, the stool is loose and contains no melena or bright blood. Between episodes of diarrhea, she occasionally has one bowel movement every 4 to 7 days; the stool is hard and "pellet-like." She drinks one glass of wine daily. Physical examination shows no abnormalities. Laboratory studies show:
Hemoglobin 14.3 g/dL
Hematocrit 43%
Leukocyte count 8100/mm3
Erythrocyte sedimentation rate (Westergren) 7 mm/h
Which of the following is the most likely diagnosis?
A) Crohn's disease
B) Colon cancer
C) Diverticulitis
D) Irritable bowel syndrome
E) Small bowel lymphoma
F) Ulcerative colitis
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* Re:nbme q 136
#554217
michaelis - 11/10/06 22:34
dd
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* Re:nbme q 136
#554279
myusmle - 11/10/06 23:02
ok D -- IBS
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* Re:nbme q 136
#554284
pranju - 11/10/06 23:05
ddddd
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* nbme 129
#137656
myusmle - 11/10/06 22:29
A 65-year-old woman develops a proximal deep venous thrombosis 1 week after an elective total hip replacement. What is the mechanism of intravenous heparin in treating this disorder?
A ) Activation of plasmin
B ) Facilitation of inactivation of thrombin by antithrombin III
C ) Inhibition of activation of tissue plasminogen
D ) Inhibition of vitamin K-dependent coagulation factors
E ) Reversible inhibition of protein C and protein S activity
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* Re:nbme 129
#554232
rmansour - 11/10/06 22:38
BBB
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* Re:nbme 129
#554257
myusmle - 11/10/06 22:51
yes B
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* Re:nbme 129
#554268
pranju - 11/10/06 22:57
bbbbbbbbbb
nbme 131
#137658
myusmle - 11/10/06 22:29
A 30-year-old woman has a 10-month history of a whitish discharge from both breasts. Her last menstrual period was 9 months ago. She had a bilateral tubal ligation 4 years ago after the birth of her third child. Palpation of the breasts discloses no masses. Whitish fluid is expressed bilaterally on compression of the nipples. The most likely diagnosis is
A ) bilateral mastitis
B ) intraductal carcinoma of the breast
C ) metastatic carcinoma of the breast
D ) pituitary adenoma
E ) premature menopause
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* Re:nbme 131
#554209
rmansour - 11/10/06 22:31
DDD: SHE HAS A PROLACTINOMA CAUSING GALACTORRHEA.
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* Re:nbme 131
#554267
myusmle - 11/10/06 22:56
D-- Amenorrhea ,galactorrhea ,no masses, cannot be preg coz tubes ligated
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nbme 128
#137655
myusmle - 11/10/06 22:28
A 47-year-old man undergoes resection of his entire stomach for intractable bleeding from a gastric ulcer. After recovery, he is at increased risk for which of the following?
A ) Copper deficiency
B ) Vitamin A deficiency
C ) Vitamin B6 (pyridoxine) deficiency
D ) Vitamin B12 (cyanocobalamin) deficiency
E ) Vitamin C deficiency
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* Re:nbme 128
#554219
steponestart - 11/10/06 22:35
d? lost parietal cells
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* Re:nbme 128
#554254
myusmle - 11/10/06 22:50
yes D -- no intrinsic factor due to loss of parietal cells
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* Re:nbme 128
#554258
pranju - 11/10/06 22:51
dddddddddd
* nbme q 126
#137653
myusmle - 11/10/06 22:28
A 45-year-old man has nausea, vomiting, and abdominal pain. He has tachycardia, absent bowel sounds, and involuntary guarding and rebound tenderness of the abdomen. The most likely cause of these findings is
A ) cholecystitis
B ) gastritis
C ) gastroenteritis
D ) peritonitis
E ) small bowel obstruction
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* Re:nbme q 126
#554238
rmansour - 11/10/06 22:42
PROBABLY D?
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* Re:nbme q 126
#554244
myusmle - 11/10/06 22:46
yes D --guarding and rebound tenderness-- peritonitis
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* Re:nbme q 126
#554256
pranju - 11/10/06 22:50
DDDdddd
nbme q 133
#137660
myusmle - 11/10/06 22:31
An 85-year-old woman who was admitted to the hospital 3 days ago for myocardial infarction has a radionuclide scan that shows damage to the anterior wall of the left ventricle. Which of the following coronary vascular structures was most likely occluded?
A) Circumflex artery
B) Coronary sinus
C) Left anterior descending artery
D) Posterior descending artery
E) Right coronary artery
F) Right marginal artery
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* Re:nbme q 133
#554211
rmansour - 11/10/06 22:32
CCC