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A middle age patient presents with history of tiredness, pain in his abdomen, and sexual dysfunction. Blood lab results shows a decrease serum haptoglobin, and a normocytic anemia with pancytopenia. Sucrose hemolysis test was positive. The patient's condition is most likely attributed to which of the following

A. Intrinsic hemolytic anemia/extravascular hemolysis
B. Extrinsic hemolytic anemia/intravascular hemolysis
C. Intrinsic hemolytic anemia/intravascular hemolysis
D. Extrinsic hemolytic anemia/extravascular hemolysis
E. Positive Direct Coomb™s Test/extravascular hemolysis

C

MY GUESS

sucrose test compliment system gets activated-PNH
B

bbb sickle cell anemia

yeah its PNH but ans is CCCCC...

CC

can som1 explain please?

cc

think its C.......ans with explanation pls

cd 55 and cd 59 deficiency also known as DECAY ACCELERATING FACTOR DEFICIENCY

SO complement mediated killing of RBC occurs..mostly dark colour uring in morning..due to overnight collection

so its intrinsic defect and intravascular destruction.
got it???