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Warfarin and Aspirin is a bad combination of drugs to be on because of the risk of bleeding. This is due to:
1) Warfarin activates AT III, while Aspirin blocks synthesis of PGI2
2) Warfarin decreases matabolism of Aspirin
3) Warfarin prevents proper liver synthesis of clottong factors, while Aspirin increases bleeding time
4) aspirin increases blood Warfarin levels
5) Aspirin allosterically increases warfarin activity

A) 1
B) 2
C) 3
D) 4
E) 5
F) 2 & 3
G) 3 &4
H) 4 & 5
I) 3 &5

G 3 and 4
warfarin mech of action is decrease level of syntheisi of vit k dependent clotting factors and
Aspirin causes increased bolld level of warf becoz warf is weak plasma protein bound so many drugs like ASA and antibiotics displaces them from plasma protein and increase their drud level..........

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answer's GGGGG. very well done everyone, and basicq's explanation is a 100% right!