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Cocaine "Direct effect" on blood vessel to produce vasoconstriction by:

1-Endothelin(potent vasoconstrictor) release from endothelial cells
2-Inhibiting Nitric Oxide production

here are the links..

*page 14 (first paragraph middle part)
http://books.google.com/books?id=g14JiT4...&q&f=false

*page 787 on the left look for highlighted Endothelin
http://books.google.com/books?id=WuA4LsW...01&f=false

http://books.google.com/books?id=kNDzFS1...01&f=false

thanks sarim

thank u so much!!!!
great help

what do u think about
NBME6, section 1, q27( b/w omeprazole and cimetidine) and q28( transformation)
thanks