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Which of the following is most likely explanation for the emergence oo HIV resistant strains to antiviral drugs?

a - CD4 is expressed on many cells
b - HIV can bind many co-receptors
c - HIV reverse transcriptase is error prone
d - Nef is capable of decresing cell surface expression of many surface proteins
e - Rev efficiently exports viral mRNA from the nucleus

CCC

Please explain it...

If the reverse transcriptase is error prone then the viral proteins that are coded by the reverse transcript would be mutating, if the drug binding site is mutated then the drug would no longer work on that protein. which would lead to resistance development.

thanks quest123.. you are right..