Toxins if damages kidneys overall not causes rash eosinophiluria fever oliguria but if causes interstitial damage causes all above is it. Like that could u pls clear this concept
well, AIN is hypersensitivity reactoin involve both cellular and humoral immunity cause defuse inflamation (fever, rash, inflamatory mediator accumulatoin) and drug molicule also bind with tubular basement membrene cause oliguria, esonopliluria.overall it is reversable.
where as toxin induced renal damage is due to vesoconstriction or direct cell injury , various degree of renal failore.