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43. A molecular defect in the basement membrane components of skin will cause which of the following skin conditions?



a) Chronic blistering

b) Dry scaling skin

c) Keloid formation

d) Proliferation of cutaneous nevi

e) Thick cornified skin

aa

why? please explain. thanks.

because, it is a Bullous Pemphigoid(antibodies against hemidesmosomes(AKA epidermal basement membrane).

but blisters are present in pemphigus vulgaris too, where the antobodies are directed towards desmosomes.

could anyone come up with a better explaination?

A
Hemidesmosome : connects keratin of in basal cells to the underlying basement membrane.

aa