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A 25-year-old woman presents with increasing obesity, amenorrhea, hypertension, and abdominal stria. Which of the following is the next best diagnostic test?
A. Prolactin
B. Free T4 and TSH
C. Overnight dexamethasone suppression test
D. Random cortisol
E. ACTH

E please.

C. Overnight dexamethasone suppression test

Its C. Overnight dexametasone supression test to detect Cushings Syndrome

The right anwser is C).

Explanations:
This patient presents with a high suspicion for Cushing's syndrome. The initial step in the evaluation should be an overnight dexamethasone suppression test. Failure to suppress would indicate high likelihood of Cushing's syndrome. A random cortisol is not sufficient to screen for Cushing's syndrome. An ACTH by itself is not useful.