A 40-year-old woman presents to the doctor complaining of palpitations. She was diagnosed with diabetes a few years ago but has otherwise been healthy. Physical examination is notable for jaundice. Laboratory results are notable for aspartate aminotransferase 100 U/L, alanine aminotransferase 112 U/L, and serum fasting glucose 145 mg/dL, and liver biopsy reveals significantly elevated iron levels
Which of the following laboratory values is seen in this disease?
a decreased ratio of serum iron to TIBC
b decrease serum ceruloplasmin
c decrease serum ferritin
d decrease serum transferritin saturation
e increase TIBC
BBB
because it is produced in the liver which is impaired in this patient who is suffering from hemochromatosis.
I think transferrin saturation increases because you have excess iron to bind to transferrin
Lab findings in hemochromatosis:
Iron levels — Most people with hemochromatosis have elevated levels of iron in the blood.
Transferrin saturation — Transferrin is a protein that binds iron and transports it between the tissues. Transferrin saturation is calculated from iron levels in the blood. The transferrin saturation increases as the body's iron stores increase. This test is one of the most sensitive tests for detecting early hemochromatosis. A transferrin saturation greater than 45 percent should be investigated further.
Ferritin levels — Ferritin is a protein that reflects the body's stores of iron. Blood ferritin levels increase when the body's iron stores increase; however, levels of ferritin usually do not rise until iron stores are high. Therefore, the results of this test may be normal early in the course of hemochromatosis.
Ferritin levels greater than 300 ng/mL in men and 200 ng/mL in women support a diagnosis of hemochromatosis. However, ferritin levels can also be increased by many common disorders other than hemochromatosis.
@cardio, why you chose AA, FA 2013 page 357 says in the table that the ratio of serum iron to TIBC is increased?? in hemochromatosis, increased serum iron, increase ferritin, decreased TIBC, increased transf saturation, so why you chose aa?? please cardio explain?? thank you dear