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A 45 year old man presents to your office for follow up of his dyslipidemia that was diagnosed 6 month. His lipid panel at that time was consistent with high Total cholesterol , Low HDL and high triglyceride levels. He was instructed on dietary modification. He presents for a follow up visit today and reports that he had been strictly compliant with reduced fat diet. His social history is significant for smoking 1 pack per day for the past 25 years . He reports drinking about 1 pint vodka per day for past 10 years. He read on an online magazine that drinking alcohol would boost his “Good” cholesterol. At this time, a repeat fasting lipid profile reveals:

Total Cholesterol : 250mg%

HDL cholesterol : 35mg%

Triglycerides: 500mg%

The most important step at this time to address his lipid abnormalities:

A) Niacin

B) Gemfibrozil

C) Fenofibrate

D) Alcohol cessation
Education should be focus on, alcohol cessation.
fenofibrate
C. fenofibrate

TOO high cholesterol?? ---> STATINS. if still high---> ADD ezetimibe
TOO low HDL?? want to increase it??----> Nyacin
TOO high lipids??---> Fibrates. if still high---> ADD nyacin

NEVER combine statins + fibrates => severe myositis with rhabdomyolisis

but wait.. I just realized gemfibrozil and fenofibrate are both fibrates LOL.
its trap people hahaha, whats the answer??
oh yaaa.... good observation interferon
then alcohol cessation is the best answer
u cant have two best answers on the exam
correct Answer D

stoping alcohol is best answer
Thank you for Q.
@medplus thanks!good q, theres not so much info on uworld on hyperlipidemia lifestyle changes, on CAD and DM is very clear but not so much in this topic, if there is please someone post the QID. however I found this on updtodate

*Lipid levels can be lowered with lifestyle changes, medications, or a combination of these approaches. In certain cases, a healthcare provider will recommend a trial of lifestyle changes before recommending a medication.

Lifestyle changes — All patients with high LDL cholesterol should try to make some changes in their day-to-day habits, by reducing total and saturated fat in the diet, losing weight (if overweight or obese), performing aerobic exercise, and eating a diet rich in fruits and vegetables.


FRUITS AND VEGETABLES

A number of studies have demonstrated important health benefits of eating fruits and vegetables.

●Increased intake of fruits and vegetables is linked to a lower risk of premature death.
●Fruits and vegetables decrease the risk of cardiovascular diseases including coronary heart disease (CHD) and stroke, including death from CHD [1].
●High intake of fruits and vegetables also reduces the risk of developing certain kinds of cancer (including lung cancer and cancer of the gastrointestinal system). Tomato and tomato-based foods may be beneficial at lowering the risk of prostate cancer.
●At least five servings of fruits and/or vegetables should be eaten daily.
FIBER

Eating a diet that is high in fiber can decrease the risk of coronary heart disease, stroke, colon cancer, and death [2,3]. Eating fiber also protects against type 2 diabetes, and eating soluble fiber (such as that found in vegetables, fruits, and especially legumes) may help control blood sugar in people who already have diabetes. (See "Patient information: High-fiber diet (Beyond the Basics)".)

The recommended amount of dietary fiber is 25 grams per day for women and 38 grams per day for men. Many breakfast cereals, fruits, and vegetables are excellent sources of dietary fiber. By reading the product information panel on the side of the package, it is possible to determine the number of grams of fiber per serving (figure 1). A list of the fiber content of a number of foods can be found in the table (table 1).

FAT

Eating foods higher in healthy fats and lower in unhealthy fats may reduce the risk of coronary heart disease.

The type of fat consumed appears to be more important than the amount of total fat. Trans fats should be avoided in favor of polyunsaturated fats, particularly those polyunsaturated fats found in fish (omega 3). Other sources of polyunsaturated fats that may be beneficial include certain oils and nuts.

Trans fats are those that are solid at room temperature, and are found in many margarines and in other fats labeled "partially hydrogenated." Another major source is oils that are maintained at high temperature for a long period, such as in fast food restaurants.

Although saturated fats (found in animal products such as cheese, butter, and red meat) have typically been viewed as unhealthy, and monounsaturated fats (found in combination with other fats in many oils) as healthy, newer evidence suggests that saturated and monounsaturated fats do not significantly increase or decrease the risk of coronary heart disease, although saturated fats raise cholesterol levels.

It is important not to replace fat with refined carbohydrates (eg, white bread, white rice, most sweets). Increases in refined carbohydrate intake may lower levels of high density lipoprotein (HDL) cholesterol (good cholesterol), which actually increases the risk of coronary heart disease.

FOLATE

Folate is a type of B vitamin that is important in the production of red blood cells. Low levels of folate in pregnant women have been linked to a group of birth defects called neural tube defects, which includes spina bifida and anencephaly. Vitamins containing folate and breakfast cereal fortified with folate are recommended as the best ways to ensure adequate folate intake.

However, supplements containing folate (called folic acid) are no longer recommended to reduce the risk of heart disease.

ANTIOXIDANTS

The antioxidant vitamins include vitamins A, C, E, and beta-carotene. Many other foods, especially fruits and vegetables, also have antioxidant properties. Studies have not clearly shown that antioxidant vitamins prevent cancer, and some studies show they may actually cause harm. There is no evidence to support antioxidant vitamin supplementation for individuals who do not have specific vitamin deficiencies.

CALCIUM AND VITAMIN D

Adequate calcium and vitamin D intake are important, particularly in women, to reduce the risk of osteoporosis. A healthcare provider can help to decide if supplements are needed, depending upon a person's dietary intake of calcium and vitamin D (table 2). Although the optimal level has not been clearly established, experts recommend that premenopausal women and men consume at least 1000 mg per day and postmenopausal women should consume 1200 mg per day. No more than 2000 mg of calcium should be consumed per day. (See "Patient information: Calcium and vitamin D for bone health (Beyond the Basics)".)

The current recommendation is that postmenopausal women with or at risk for osteoporosis consume at least 800 International Units of vitamin D per day. Lower levels of vitamin D are not as effective while high doses can be toxic, especially if taken for long periods of time. Although the optimal intake has not been clearly established in premenopausal women or in men with osteoporosis, 400 to 600 International units of vitamin D daily is generally suggested.

ALCOHOL

Moderate alcohol intake may reduce the risk of heart disease. However, it is not clear what amount of alcohol is best. There are some risks associated with alcohol use, including breast cancer in women; cancers of the mouth, esophagus, throat, larynx, and liver; other illnesses such as cirrhosis and alcoholism; and injuries and other trauma-related problems, particularly in men. (See "Patient information: Risks and benefits of alcohol (Beyond the Basics)".)

Based on the trade-off between these risks and benefits, the United States Dietary Guidelines recommend alcohol intake in moderation, if at all. This means no more than one drink per day for women, and up to 2 drinks per day for men. Those who do not drink alcohol do not need to start.

Drinking is discouraged for those under 40 years who are at low risk of cardiovascular disease because the risks are likely to outweigh the benefits in this group.

CALORIC INTAKE

Calories count. Too many calories lead to weight gain and obesity. It is linked with premature death as well as an increased risk of cardiovascular disease, diabetes, hypertension, cancer, and other important diseases [4-8].

The total number of calories a person needs depends upon the following factors:

●Weight
●Age
●Gender
●Height
●Activity level
GENERAL RECOMMENDATIONS FOR A HEALTHY DIET

Eat lots of vegetables, fruits, and whole grains and a limited amount of red meat. Get at least five servings of fruits and vegetables every day. Tips for achieving this goal include:

●Make fruits and vegetables part of every meal. Eat a variety of fruits and vegetables. Frozen or canned can be used when fresh isn't convenient.
●Eat vegetables as snacks.
●Have a bowl of fruit out all the time for kids to take snacks from.
●Put fruit on your cereal.
●Consume at least half of all grains as whole grains (like whole wheat bread, brown rice, whole grain cereal), replacing refined grains (like white bread, white rice, refined or sweetened cereals).
Cut down on unhealthy fats (trans fats and saturated fats) and consume healthy fats (polyunsaturated and monounsaturated fat). Tips for achieving this goal include:

●Choose chicken, fish, and beans instead of red meat and cheese.
●Cook with oils that contain polyunsaturated and monounsaturated fats, like olive and peanut oil.
●Choose margarines that do not have partially hydrogenated oils. Soft margarines (especially squeeze margarines) have less trans fatty acids than stick margarines.
●Eat fewer baked goods that are store-made and contain partially hydrogenated fats (like many types of crackers, cookies, and cupcakes).
●When eating at fast food restaurants, choose healthy items for yourself as well as your family, like broiled chicken or salad.
Avoid sugar-sweetened beverages and excessive alcohol intake. Tips for achieving this goal include:

●Choose non-sweetened and non-alcoholic beverages, like water, at meals and parties.
●Avoid occasions centered around alcohol.
●Avoid making sugar-sweetened beverages and alcohol an essential part of family gatherings.
Keep calorie intake balanced with needs and activity level.

anyone can see it AT: http://www.uptodate.com/contents/diet-an...e=see_link
http://www.uptodate.com/contents/high-ch...e=see_link