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A 45-year-old woman has noted a mass in her right breast for 7 months. On physical examination there is a 5 cm diameter right breast mass. A biopsy of the mass is performed and on microscopic examination a carcinoma is present. Which of the following pathologic findings involving this lesion suggests a better prognosis for this woman?

A Estrogen receptor negative

B Axillary lymph node metastasis

C Age at diagnosis

D Aneuploidy by flow cytometry

E Intraductal histologic pattern

The best overall survival is with intraductal carcinomas (those that have not invaded out from the ducts); this is the lowest stage possible.