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An 18-month old child suffers recurrent bacterial infections. Upon immunologic evaluation, he is found to have age-normal numbers of CD 19+ cells and CD3+ cells in the blood as well as extreme neutrophilia. Nitroblue tetrazolium dye reduction test is normal. In this child, the most likely defect is absence of

A. CCR4
B. CD18
C. IL-1
D. IL-4
E. TNF-a

ee

C is it?

Why C? or E? Please explain your answer.

b

LAD def

BBB thanks a lot for the question, totally forgot about neutrophilia in LAD def. thanks

Yes, B is correct.

Diagnosis is Leukocyte Adhesion Deficiency, a genetic deficiency of CD18 required for the process of migration of neutrophils to sites of inflammation.

You are welcome