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+--- Thread: Difference between ITP & TTP - harrisonusmle (/showthread.php?tid=568376)
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Difference between ITP & TTP - harrisonusmle - ArchivalUser - 02-15-2011
Hi
Can you explain how to differentiate between ITP & TTP?
Thanks in advance
0 - ArchivalUser - 02-15-2011
ITP-- Fever, anemia and thrombocytopenia.TTP-along with renal dysfunction and neurological symptoms
0 - ArchivalUser - 02-15-2011
and how do u differentiate that in the lab?
0 - ArchivalUser - 02-15-2011
i harrison !
i think ITP is with out splenomegaly and the other with it ????correct me
0 - ArchivalUser - 02-15-2011
Labs-ITP-incresed megakaryocytes,TTP--Schistocytes and Increased LDH
0 - ArchivalUser - 02-15-2011
TTP---------schistocyte,fever ,renal dysfunction
ITP--------------No cause : Ab against platelet.
Anything else
@Puo i think in ITP splenomegaly there
0 - ArchivalUser - 02-15-2011
the main lab. diff . is that LDH increased in TTP and it is normal in ITP
0 - ArchivalUser - 02-15-2011
can any one say , wat is the importance of LDH >??
0 - ArchivalUser - 02-15-2011
ITP = auto imnune destruction of RBCs by the spleen
TTP= Pentad of Microangiopathic hemolytic anemia, fever, CNS symtoms, renal failure, thrombocytopenia
Intravascular hemolysis will lead to inc. LDH & AST.
0 - ArchivalUser - 02-15-2011
how to diff TTP and HUS ??