09-26-2006, 08:56 PM
how do u get malabsorption if there is a defect in cystic fibrosis transmembrane regulator on chrmosome 17?
mechanism?
mechanism?
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cystic fibrosis? - iced
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09-26-2006, 08:59 PM
chloride channel blockade..can you explain it for revision?
09-26-2006, 09:09 PM
too much mucus plugs pancreatic ducts....leading to pancreatic nsufficiency....lemme finish offering my prayers...tehn i will get back
09-26-2006, 09:12 PM
if cystic fibrosis transmembrane regulator on chromosome 17 is defective then u have a problems with secretions they become thicker and blocks the ducts in the glands that were making fluids in the pancreas ..the exocrine part...so if u block the lumen there is a back pressure on the pancreas and it atrophies resulting in malabsorption....
its just like atrophy of cortex and medulla in kidney when there is a back pressure related to urine..the same thing happens here in pancreas when there is a back pressure due to blocked ducts..by thick secretions ...>atrophy of pancreas and other glands too.... |
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