04-26-2012, 11:01 AM
which of the following genes allows down regulation of MHC 1 molecule expression in HIV?
a)POI gene
b)Gag gene
c)ENV gene
d)NEF gene
e)Tat gene
a)POI gene
b)Gag gene
c)ENV gene
d)NEF gene
e)Tat gene
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WHICH OF THE fOLLOWING? - zen786
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04-26-2012, 11:05 AM
Hi Zen can you please briefly explain the function of all genes...thnx
04-26-2012, 11:12 AM
correct answer is D:
@timmalik Sure can friend  a)POI gene: provides reverse transcriptase [creates dsDNA from RNA hiv], integrase [integrates viral dna into host], protease [cleaves viral protein] b)Gag gene: provides p24 [capsid protein], p7p9 [core nueclocapsid protein], p17 [matrix protein] ... c)ENV gene: provides gp120 [surface protein that binds to ccr5 & cd4 on macropages ..... and also binds to cxcr4 and cd4 on t-cells] ....provides gp41 : thats the transmembrane protein for viral fusions to host cell d)NEF gene: provides down regulation of mhc1 expression & cd4 - without this gene you can not progess to AIDS e)Tat gene: provides inhibits cytokine in cells & destroys Th1 cells & upregulation of transcription [HIV] |
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