06-05-2017, 08:41 PM
Which of the following modifications of an endogenous pharmacologically active peptide would be most likely to slow the metabolism of the peptide, thus decreasing its clearance and increasing its half-life?
A ) Administering the peptide with an enteric coating
B ) Decreasing the number of amino acids in the peptide
C ) Ensuring a free amino group at the N terminal
D ) Ensuring a free carboxyl group at the C terminal
E ) Substituting a D for an L amino acid
A ) Administering the peptide with an enteric coating
B ) Decreasing the number of amino acids in the peptide
C ) Ensuring a free amino group at the N terminal
D ) Ensuring a free carboxyl group at the C terminal
E ) Substituting a D for an L amino acid