Waldenstroms macroglobulinemia - bijjar

[ArchivalUser]

Monoclonal IgM, usually in older men
Hyperviscosity occurs responds to plasmapherisis
Binds to platelets and clotting factors----leads to---Epistaxis and ginbival bleeding
Binds to peripheral nerves____leads to peripheral neuropathy

(any Question which ask this diease, important for exam, plz post it, thank)

[ArchivalUser]

asssociated with lymphadenopathy and hepatomegaly in contrast from MM
renal involvement is very rare
hypercalcemia and bone lesions are also rare
fludarabine may be used in treatment