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ben or anyone there to help? - fatimabk
#1
difference btw erythema multiforme,SJ syndrome,and TOXIC epidermal necrolysis...i am confused.thanks in advance......
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#2

MAY BE U LL FND THIS HELPFUL


Erythema Multiforme



Considered a hypersensitivity syndrome, erythema multiforme (EM) presents with characteristic target or iris-shaped papules and vesicobullous plaques These lesions are frequently cutaneous manifestations of a drug reaction, viral infection, Mycoplasma, or malignancy. These plaques are usually symmetric, pruritic, and painful, often involving the mucous membranes and extremities, including the palms and soles. The milder form of the disease has minimal mucosal involvement, no bullae, and no systemic symptoms.

Stevens-Johnson Syndrome (EM Major)
abrupt onset of constitutional symptoms precedes the hemorrhagic bullae found on multiple mucosal surfaces and the edematous, erythematous cutaneous plaques The bullae erode, producing stomatitis, conjunctivitis, vulvovaginitis, or balanitis. Patients appear extremely ill and may develop pneumonia, arthritis, seizures, coma, and hepatic dysfunction. Death, when it occurs, is usually due to overwhelming sepsis.
Fever, malaise, extensive mucosal involvement, and other constitutional symptoms are noted in the severe form of EM, known as Stevens-Johnson syndrome


Toxic epidermal necrolysis (TEN)
is characterized by the formation of erythematous (scalded) skin followed by widespread bullae ( usually a cutaneous manifestation of a drug reaction. The epidermis eventually becomes necrotic, leading to extensive exfoliation and exposure of the raw dermis A prodrome of fever, fatigue, myalgias, and skin tenderness occurs in the majority of patients. The mortality rate approaches 25%, with death usually due to sepsis or gram-negative pneumonia. TEN is generally considered to be the most severe form of erythema multiforme.


so in short IN ORDER OF INCREASING SEVERITY

EM(MINOR)------------EM-MAJOR(SJ-syndrome)-----------TEN
SJS <10% epidermal detachment
SJS/TEN overlap 10% to 30% epidermal detachment.
TEN >30% epidermal detachment.

NIKOLYSKYS SIGN IS POSITIVE IN SJ N TEN
ITS ALSO POSITIVE IN SSS AND PEMPHIGS VULGARIS
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#3
thanks a lot 8888888...
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