05-22-2007, 08:56 AM
a 2 yr girl is below 5th percentile for her ht and wt,no other abnormalitiesmgenetic screening show s a new mutation in the ADH V2 receptor,water is restricted for 12 hrs to test functional significance of the mutation,at end of 12 hrs which of the following will most likely confirm aloss of function defect in th V2 receptor
serum ADH increase /decrease
serum osmolarity increase/decrease
Urine osmolarity 200/ 600
serum ADH increase /decrease
serum osmolarity increase/decrease
Urine osmolarity 200/ 600