malonyl-CoA increase - proteus

[ArchivalUser]

As levels of malonyl-CoA increase in the cytosol, how will the enzyme carnitine acyltransferase I be affected?

A. Malonyl-CoA stimulates carnitine acyltransferase I
B. Malonyl-CoA is a substrate of carnitine acyltransferase I
C. Malonyl-CoA has no effect on carnitine acyltransferase I.
D. Malonyl-CoA inhibits carnitine acyltransferase I

[ArchivalUser]

Choice (D) is the correct answer. Malonyl-CoA is a precursor in fatty acid synthesis. To prevent futile cycling between fatty acid synthesis and beta-oxidation, malonyl-CoA inhibits carnitine acyltransferase I, which is a key regulatory enzyme in the carnitine shuttle. The carnitine shuttle transports activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where beta-oxidation occurs. The other choices are incorrect.

[ArchivalUser]

thank u proteus for helping us all...really appreciate ur effort

[ArchivalUser]

thanks ...keep going plz with answ!