07-17-2008, 07:01 AM
is the given enswer d correct?
whats wrong with e??
whats wrong with e??
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NBME 4 Block 3 Q49 - vitf
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07-17-2008, 07:12 AM
Midazolam should be administered with caution to the elderly (> 60 years), debilitated and higher risk adult surgical patient) as reduced dosages of midazolam may be required. The elderly are more sensitive to effects such as drowsiness, hypoxemia, and depressed ventilation. it is part of the Contraindications/Precautions of the drug but the concept (all Benzodiazepines) see FA Midazolam is widely distributed, crossing both the blood-brain and placental barriers(R/0) The volume of distribution (VD) , also known as apparent volume of distribution, is used to quantify the distribution of a medication throughout the body after oral or parenteral dosing. It is defined as the volume in which the amount of drug would need to be uniformly distributed to produce the observed blood concentration. Volume of distribution may be increased by renal failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). Conversely it may be decreased in dehydration. The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same formula. see FA
07-17-2008, 07:46 AM
but vol of distibution also increases in elderly..
anyways d is the right answer i guess.. we have to go with the best answer
07-17-2008, 08:01 AM
see
http://www.chop.edu/consumer/jsp/divisio...p?id=72620 More than one chose it possible if you go by the age related changes increase . you choose by presented symptoms and drug given |
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