nbme 4 QqqqqqqQ - asdrty

[ArchivalUser]

a 42 y/o man has a tepmerature of 39.2 C (102.6 F) & mild jaundice 2 days after transfusion of packed red cells for the treatment of chronic anemia. laborarory studies show hyperbilirubinemia & amild increase in serum lactate dehydrogenase activity. which of the following findings will most likely be observed on analysis og peripheral blood cells?

A) complement protein C3bi bound to monocytes
B) degranulated neutrophils
C) erythrocyte ghosts
D) HLA-DR upergulation in circulating CD3+ T lynphocytes
E) immunoglobulin bound to erythrocytes
F) nucleated erythrocytes

plZZZZZZZZZZZZZ explain nbme 4-4-16

[ArchivalUser]

E..?

[ArchivalUser]

EEE "Delayed Hemolytic Transfusion Rxn"

since the pt has chronic anemia he must have recieved and exposed to previously transfused blood and formed antibodies.Over the period of time these antibodies subside But upon subequent exposure they reappear(Anemnestic response--recollection) which takes Atleast 24 hrs and they bind to donor R.B.Cs----and this is why its a DELAYED -respose.

[ArchivalUser]

yes it is e ...history of chronic anemia so he must have previous transfusions ...minor anitgenic difference in rbc s of matched trasfused blood elicits humoral response which is usually mild but can manifest as increase in bilrubin and lhd....

[ArchivalUser]

any other idea? what is erythrocyte ghost?

[ArchivalUser]

ans is eeeeeee but no idea ery.ghost i waiting for exp.