Thread Rating:
  • 0 Vote(s) - 0 Average
  • 1
  • 2
  • 3
  • 4
  • 5
NBME form 12 block 2 q 43 - hnin
#1
In a study of mutation that reduce the activity cytoplasmic enzymes, A mutation is found that results in substituting of an alanine residue for the serine residue normally present at position 127 in the enzyme, This mutation is most likely to reduce the activity of the enzyme by preventing which of the following?
A) Attachment of famesyl groups
B) Attachment of N linked oligosaccharides
C) Formation of disulfide bonds
D) Phosphorylation of the enzyme
E) Targeting the enzyme to the correct cellular location
MY answer is B
Please correct me if I wrong
Reply
#2
i think it should be d... as serine and threnione participate in phophorylation...
Reply
#3
Thank you, bedidee.
Reply
#4
u r welcome...
Reply
#5
ddd. b/c serine is usually the phosphorylation site for lots of signaling pathway. like MAPK. INSULINE()
Reply
#6
plz explain ....
Reply
#7
In prokaryotic proteins phosphorylation occurs on the serine, threonine, tyrosine, histidine or arginine or lysine residues.
Reply
#8
S T T H A L thankyu
Reply
« Next Oldest | Next Newest »


Forum Jump: