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A 25-year-old man presents at onset of (mitochondrial) myopathy, encephalopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS). Morphologic studies of biopsied muscle tissue reveal abnormal mitochondrial proliferation with several cytochrome-c oxidase (COX)-negative fibers. Biochemically, there is partial COX deficiency. Mutation in what gene is most likely?
A. ATPase subunit 6 gene
B. Mitochondrial rRNA gene
C. Mitochondrial tRNA gene
D. Oxidative phosphorylation (OXPHOS) regulatory gene
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@ lamonti
That is cheating....U gotta answer from your memory...LOL !!!
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**C**
Mutations in MELAS and myoclonic epilepsy with ragged red fibers (MERRF) are generally caused by mutations that impair the functioning of the mitochondrial-specific tRNAs. This ultimately impacts the translation of all mitochondrially encoded genes.
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Did none here watches House MD!
As for me I memorize House.
This was the diagnosis in the episode where the alcoholic kid has a seizure and slips in coma while his father was woken up from the 10yr old coma to answer 'family history'!
The coma dad took house n wilson to atlantic city in search of a burger/snadwich.......
Its the episode where House reveals why he becomes a doctor!
I think it was called 'Son of Coma Man'
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gotta watch it than acetheboards lol.... house md =D
