01-19-2012, 12:14 PM
I chose autosomal recessive but after the exam and after thinking thoroughly we can see that the fact that both the affected children got different alles from their mothers who is not affected ( might be carrier ) means that both of the alleles from the mother do not carry disease so it would not be recessive.
anticipation in every generation ealier and more severe symptoms was not shown in the stem of the question and is neither shown in the pedigree
Mitochondrial inheritance would show mother to all children transmission
Genomic imprinting happened here by the following:
the alleles at locus b in bd is active working but the allele b at bc and bf were imprinted methylated which was ok in the unaffected sun cuz the allele a gave a compensation for this by it is presence but was not the case in the other offspring
anticipation in every generation ealier and more severe symptoms was not shown in the stem of the question and is neither shown in the pedigree
Mitochondrial inheritance would show mother to all children transmission
Genomic imprinting happened here by the following:
the alleles at locus b in bd is active working but the allele b at bc and bf were imprinted methylated which was ok in the unaffected sun cuz the allele a gave a compensation for this by it is presence but was not the case in the other offspring