NBME 12 Block 2 Q 43 - chuha

[ArchivalUser]

In a study of mutations that reduce the activity of a cytoplasmic enzyme, a mutation is found that results in substitution of an alanine residue for seine residue at position 127 in the enzyme.This mutation is most likely to reduce the activity of enzyme by preventing which of the following?

A. Attachment of farnesyl group

B attachment of N-linked oligosaccharide

C. Formation of disulfide bond

D. phosphorylation of enzyme

E. Targeting the enzyme to correct cellular location

I choose D thinking of phosphorylation of serine residue in tyrosine kinase receptor of Insulin

what do you say

[ArchivalUser]

D.....
amino acid with side chain OH have ability of phosphorylation of enzyme

[ArchivalUser]

can someone explain??

[ArchivalUser]

but in key it says C..........
So its wrong right.D is the correct answer