NonNBME Qn - samideb12

[ArchivalUser]

During B-globin synthesis in normal reticulocytes the sequence his-arg-pro occurs at position 165-167.How many high-energy phosphate bonds are required to insert these three amino acids into the B-globin polypeptide during translation?
A.15
B.12
C.9
D.6
E.3

[ArchivalUser]

aaa....

[ArchivalUser]

B..

[ArchivalUser]

b

[ArchivalUser]

@samideb : What's the answer ??

[ArchivalUser]

3 Amino acids need need four high-energy phosphate bonds each and you multiply that and it will give you 12

[ArchivalUser]

Initiation requires one GTP for activation ; And 4 high energy bonds ( 2 form ATP and 2 from GTP ) utilized in elongation . Doesn't that make it 15 for 3 amino acids ? Please correct me if I am wrong !

[ArchivalUser]

Only four high energy bonds are required .Check that in kaplan lecture page 55 regarding elongation.samideb

[ArchivalUser]

Ok..I got it...I was lost..the question only asks about chain elongation by inserting 3 amino acids
Thanks !