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NBME F1B1Q44- 52yo alcoholic woman & hypercholest - maritzasf
#1
Q44.

A 52-year-old woman with alcoholism comes to the physician after a serum cholesterol level of 290 mg/dL was found on a routine screening. She drinks a pint of vodka daily. She takes captopril for hypertension and glyburide for type 2 diabetes mellitus. She also has intermittent episodes of gout. Fasting serum studies show:

Total cholesterol 252 mg/dL
HDL-cholesterol 80 mg/dL
Triglycerides 300 mg/dL
Glucose 118 mg/dL
Thyroid-stimulating hormone 4.5 μU/mL

Which of the following is the most appropriate next step in management?

A) Alcohol cessation
B) Better control of diabetes
C) Switch from captopril to calcium-channel blocking agent therapy
D) Gemfibrozil therapy
E) Thyroid replacement therapy
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#2
A.
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#3
a.
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#4
Answer:
A) Alcohol cessation

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Nice explanation here at Braunwald's Wink Didn't know alcohol increased HDL Big Grin not everything is bad Wink hehe


Ethanol and Lipid Metabolism
===================

Ethanol consumption inhibits the oxidation of free fatty acids by the liver, which stimulates hepatic Triglyceride synthesis and the secretion of very low-density lipoprotein (LDL) cholesterol.

Most commonly, therefore, ethanol consumption causes hypertriglyceridemia. In addition, heavy ingestion may cause an increase in the serum concentrations of total and LDL cholesterol.

Regular ethanol consumption increases the serum concentration of high-density lipoprotein (HDL) cholesterol. Subjects with hyperlipidemia should be encouraged to limit their ethanol intake.

[Braunwald's Heart Disease - A Textbook of Cardiovascular Medicine, 9th ed. 2011]
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#5
welcome back Smile
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#6
Thank you!
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