nbme1 - poojy36

[ArchivalUser]

1.clinical trials have suggested the use of retinoc acid in the tretament of promyelocytic leukemia.such remission is related to wht ability of retinoic acid?

a)differentiation of leukemic cells
b)differentiation of monocytes to macrophages
c)generation of cytotoxic T cells
d) production of interferon
e Dna damage repair

2)22 yr old has fever ...dysuria flank pain.....vitals
temp-103f pulse 130 resp 25 bp -90/55...she has anuria and blood cultures show ecoli ...which cytokines contribute to her illness??

a)IL2 IF GAMMA
B) IL3 IL7
C)IL4 IL5
D)IL10 IL12
E)TNF ALPHA AND IL1

[ArchivalUser]

pls attempt to answer these questions

[ArchivalUser]

1. A. differentiation of leukemic cells.

2. E. TNF alpha and IL1

[ArchivalUser]

i agree with calender ===> MQ respond to LPS by producing TNF which in turn trigger cytokine cascade ( IL-1 , IL-6 , IL-8 , NO , PAF ) leading to systemic response --- > shock

[ArchivalUser]

THNKS A LOT

[ArchivalUser]

thanks, all those who are answering....i had a follow up Q.....what is the main host defense mechanism against an endotoxin?
raymon, wht u described is the outcome of endotoxic shock...can u go further an explain wch immune cells are responsible in fighting it off?

[ArchivalUser]

1. Endotoxin damage endothelial cell , releasing NO & PGI2 (vasodialators)
2. Endotoxin activate alternative comp pathway releasing anaphylatoxins (C3a C5a)==>vasodilatation)
3. MQ respond by releasing IL-1 , TNF which in turn activate neutrophil adhesion mol. causing neutrophil adherence to pulmonary capillaries .

[ArchivalUser]

great thanks! so in oneword, would it be the complement mediated cytotoxicity?