12-25-2013, 05:03 AM
Can non-competitive antagonist behave as competitive antagonist at low dose????
anyone please explain the concept
thanks
anyone please explain the concept
thanks
non competitve antagonist??? - stranger016
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12-25-2013, 05:03 AM
Can non-competitive antagonist behave as competitive antagonist at low dose????
anyone please explain the concept thanks
12-25-2013, 09:34 AM
Anyone has any idea about it guys???
12-25-2013, 09:52 AM
they are noncompetitive always at any dose, they bind to a different site than the substrate site but the bond can be covalent(reversible) or noncovalent(irreversible)
http://www.usmleforum.com/showthread.php?tid=759513 NONCOMPETITIVE INHIBITORS a. reversible (allosteric)binding -The drug binds to an allosteric site(regulatory site) -many feedback inhibition by allostric regulators in biochem reactions b. irreversible binding -Organophosphates (insecticides used by farmers) causes noncompetitive irreversible inhibition of acetylcholinesterase -ASPIRIN is the only NSAID that is noncompetitive irreversible inhibitor of COX. The other NSAIDs are competitive inhibitors of COX -Penicillin acts by covalently modifying the enzyme transpeptidase, thereby preventing the synthesis of bacterial cell walls and thus killing the bacteria
12-25-2013, 06:29 PM
thanks for that miracoli..
have u done NBME 11,if yes the can u please explain this question from NBME 11 Block 2 Q 20 http://www.usmleforum.com/showthread.php?tid=762275 |
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