Non-nbme question 4 - alina972

[ArchivalUser]

A 65-year-old man complains of muscle weakness and a dry cough for 4 months. He has smoked two packs of cigarettes daily for 45 years. A chest X-ray shows a 4-cm central, left lung mass. Laboratory studies reveal hyperglycemia and hypertension. A transbronchial biopsy is diagnosed as small cell carcinoma. Metastases to the liver are detected by CT scan. Which of the following might account for the development of hyperglycemia and hypertension in this patient?

(A) Adrenal metastases
(B) Paraneoplastic syndrome
© Pituitary adenoma
(D) Pituitary metastases
(E) Thrombosis of the renal artery

[ArchivalUser]

BBB ACTH and EPO increase?

[ArchivalUser]

BB ACTH inc Cortisol: hyperglycemia( inc gluconeogenesis, lipolysis, proteinlysis).
BP;;ƒ Upregulates α1-receptors on arterioles
Ž  sensitivity to norepinephrine and
epinephrine
ƒ At high concentrations, can bind to
mineralocorticoid (aldosterone) receptors

[ArchivalUser]

bbb

[ArchivalUser]

B is correct.