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SHBG..sex hormone binding globulin
It's synthesis is decreased by:
1. Androgens
2. Insulin
3. Obesity
4. Hypothyroidism
can someone please explain the concept of how each of the above factors decreases the synthsis of SHBG.
I know that estrogen can increase it's synth in the liver.
thanks.
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i think only androgen.. but i dont know if there is any mechanism described 4 this..
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thyriod also increse synthesis of SHBG
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ok guys..this wasn't an mcq question..maybe i shouldn't have put numbers. I was only trying to list all the conditions that decrease the synth. of SHBG. All I want to know is the concept behind how each (comditions 1-4) decrease the synth. of SHBG.
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does no one know the answer to any of these?
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all increase SHBG except HYPOthyroidism. thyroid hormone increase SHBG.
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sorry androgen and obesity will dec it
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Thank you derma....but i don't think you understood my question.
Androgens,Insulin,Obesity, Hypothyroidism ........all of these decrease the synth. of SHBG...I am asking if anyone can explain the concept of WHY for each of these..that is my question , not what decreases and what increases.
e.g. why does hypothyroidism decrease the synthesis of SHBG?
" " obeisity " " " " ? ect.
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this is a post from long back but can someone explain the concept involved - what the OP asked.
WHy SHBG is decreased by:
Androgens
Insulin
Obesity
Hypothyroidism
